Dendritic cell infiltration in Cholangiocarcinoma as a prognostic factor
Katanyoo Sawangsri1, <Others to be added>
Background: Dendritic cells (DCs) are known as the most potent professional antigen presenting cells (APCs) including tumor antigens. Several studies have shown that the presence of a high number of DCs in several tumor correlated with a good prognosis but less study in intrahepatic Cholangiocarcinoma.
Objective: To study correlation between the number of dendritic cell (CD83+) infiltration and overall survival in intrahepatic Cholangiocarcinoma.
Methods: The retrospective study, immunohistochemistry for CD83 was performed in ?? embedded specimen from patient with intrahepatic cholangiocarcinoma and undergo partial hepatectomy. The median follow up was ?? months. We analysis data that correlate between number of dendritic cell infiltration and overall survival including other prognostic factor.
Results: Of the nurses, ??.?% (95%CI: ??.? to ??.?) had been exposed to WPV, either physically or non-physically, in at least one episode during the previous 12 months. Physical violence was reported with a frequency of ??.?% while that of the non-physical violence was ??.?%. Serious WPV indicated by WPV that caused work absence was reported in ??.?% of all nurses. Factors that associated with any type of WPV, presented as odds ratio (OR) and 95%CI, included ????? (OR = ?.??; 95%CI: ?.?? to ?.??; p = 0.0??), ????? (OR = ?.??; 95%CI: ?.?? to ?.??; p = 0.0??), ????? (OR = ?.??; 95%CI: ?.?? to ?.??; p = 0.0??), ????? (OR = ?.??; 95%CI: ?.?? to ?.??; p = 0.0??), and ????? (OR = ?.??; 95%CI: ?.?? to ?.??; p = 0.0??).
Conclusions: High number of dendritic cell infiltration is independent prognostic factor in intrahepatic cholangiocarcinoma. We suggest